The intake of omega-3 FA could help to improve/maintain a healthy metabolic profile

 
 
 

Obesity can be harmful to health. Why? Because adiposity (body fat accumulation) leads to adipocyte dysfunction; adipocytes are the cells that form the adipose (fat) tissue. Although in the past it was believed that the function of adipocytes was the storage of fats, it is now known that they are specialized cells involved not only in “fuel” storage, but also in endocrine, nervous and immune function. Adiponectin is a protein secreted by adipocytes that has been suggested to be one of the causes of the development of metabolic disorders; it has been found to be decreased in cases of insulin resistance, diabetes, and atherosclerosis, among other disorders.

Excess of adiposity is accompanied by a chronic state of low-grade inflammation (in this state, levels of adiponectin are low). It is known that omega-6 fatty acids are precursors of inflammatory molecules, while omega-3 fatty acids produce anti-inflammatory molecules. But, in what extent a high dietary omega-6:omega-3 fatty acids proportion may be associated with adiposity and alterations in different molecules secreted by adipose tissue, such as adiponectin? To answer this question a study has been carried out to analyze dietary omega-6:omega-3 fatty acids proportion and its association with adiposity and serum adiponectin levels.

The outcomes of the study suggest that high dietary omega-6:omega-3 fatty acids proportion is associated with excessive adiposity and worse metabolic profile: triglycerides, glucose, insulin, etc. Adiponectin levels also showed relation with dietary omega-6:omega-3 fatty acids proportion (low proportion, lower adiponectin levels). It is assumed that an increase in the intake of omega-3 fatty acids will be followed by a decrease in the dietary omega-6:omega-3 fatty acids proportion, so, it could help to improve/maintain a healthy metabolic profile.

 

Bibliography:

Torres-Castillo N, Silva-Gómez JA, Campos-Pérez W, Barron-Cabrera E, Hernández-Cañaveral I, García-Cazarin M, et al. High dietary ω-6:ω-3 PUFA ratio is positively associated with excessive adiposity and waist circumference. Obes Facts. 2018 Aug 10;11(4):344-53.

Church C, Horowitz M, Rodeheffer M. WAT is a functional adipocyte? Adipocyte. 2012;1(1):38-45.