Long chain omega-3 slow cognitive decline


Consumption of seafood (rich in long-chain omega-3 fatty acids) has been associated with slower decline in semantic memory (which refers to words and other verbal symbols, concepts, facts or beliefs; their meaning and the relations among them) and perceptual speed (the readiness to attend accurately to some details in perception; i.e., the ability to quickly compare visual patterns or symbols).

Moderate to high long-chain omega-3 fatty acid intake has been also linked with slower rates of decline in global cognition and in several cognitive domains (that include episodic, semantic, and working memory, perceptual speed, and visuospatial ability) in APOE ε4 carriers. APOE is a gene on chromosome 19, and is involved in making a protein that helps carry cholesterol and other types of fat in the bloodstream. It has several different forms (alleles), and APOE ε4 is one of them. This variant of APOE increases a person’s risk of developing the Alzheimer’s disease and is also associated with an earlier age of disease onset. However, some people with an APOE ε4 allele never get the disease, and others who develop it do not have any APOE ε4 alleles.

Anyway, these observations reveal protective effects of one meal per week of seafood and long-chain omega-3 fatty acids against decline in multiple cognitive domains.




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