Diet and depression


Depending on WHO, depression is the fourth global burden of all diseases worldwide, and it is estimated that it will become the second by the year 2020. The percentage of success for depression drug therapy is estimated at 60-80%.
The relationship between depression and inadequate nutrient intake has been reported in many studies. Broadly, dietary patterns can be classified as “healthy” and “unhealthy”. Healthy and unhealthy diets may be associated with the risk of depression: To follow a healthy diet (for example, Mediterranean diet) is related with a lower likelihood of depression, and conversely, the likehood of experience depression is increased by unhealthy diets (for example, fast food, and low consumption of vegetables and fruits). Diverse nutrients such as omega-3 fatty acids, several vitamins, folate, magnesium, zinc, iron, copper, calcium, and tryptophan are important in the prevention and treatment of depression.
Studies about nutrient pharmacotherapies have shown positive results for EPA in the treatment of unipolar depression, meanwhile in bipolar depression, omega-3 fatty acids (EPA and DHA) have been found to have supportive evidence of eficacy, without major adverse effects in both cases.
Nutrition related factors might have an important role in prevention and treatment of depression.


Sarris J. Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders. Australas Psychiatry. 2017 Aug;25(4):369-72.

Khosravi M,Sotoudeh G, Majdzadeh R, et al. Healthy and Unhealthy Dietary Patterns Are Related to Depression: A Case-Control Study. Psychiatry Investig. 2015;12(4):434-42.