DHA offers vision protection, acting as a vaccine


Preconditioning is the capacity that have cells, tissues and organs to protect themselves from a lethal stimulus, which has been previously acquired by the exposition to a sublethal stimulus. DHA and its derivatives, the docosanoids, are required to enable of preconditioning of the pigmented and photoreceptor cells in the retina (photoreceptors are the cells that begin the process of seeing; they absorb and convert light into electrical signals which are sent to other cells in the retina and ultimately through the optic nerve to the brain, where they are processed into the images we see).

Preconditioning protection of these cells is crucial, because the pigmented cell layer of retina has multiple functions of great importance for vision that include physical, optical, metabolic/biochemical, and transport; and it helps to maintain an optimal environment for photoreceptor cells function. For example, the retinal pigment epithelium is important in the regeneration of visual pigments that have been altered by the absorption of light.

DHA and its derivatives are not only important but necessary for this kind of protection of photoreceptor and retinal pigmented cells.


Knott EJ, Gordon WC, Jun B, et al. Retinal Pigment Epithelium and Photoreceptor Preconditioning Protection Requires Docosanoid Signaling. Cell Mol Neurobiol. 2017 Nov 24. [Epub ahead of print] https://link.springer.com/article/10.1007%2Fs10571-017-0565-2

Retinal Pigment Epithelium [Internet]. Science Direct, Elsevier B.V., 2017. Disponible en: https://www.sciencedirect.com/topics/neuroscience/retinal-pigment-epithelium

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